CORRELATION BETWEEN SMOKING, SERUM SEROTONIN LEVEL, PERIPHERAL FATIGUE OF KNEE EXTENSORS AND KNEE PROPRIOCEPTION: CROSS-SECTIONAL STUDY

Not Applicable

• Conditions: Circulatory System; Musculoskeletal Diseases; Nervous System Diseases

• Registration Number: PACTR202201548823946
• Lead Sponsor: Cairo University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-01-21
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

1.Subjects with age 20-45 years (WHO, 2009).
2.Body Mass Idex from 18.5- 24.9 km/m2.
3.Males Subjects only.
4.Smokers who smoked 4_5 cigarettes a day for the last 5 years.
5.Nonsmokers males with serum cotinine levels less than 10 ng/ml.
6.Light and moderate smokers with serum cotinine levels of 10–100 ng/ ml.
7.Heavy smokers with serum cotinine levels above 300 ng/ml.
8.Smoking will be restricted to cigarettes.

Exclusion Criteria

1.Diabetic patients
2.Patients who receive antidepressants.
3.Hypertensive patients.
4.Cardiac patients
5.Athletic patients.
6.Patients with a history of knee pain.
7.Knee Osteoarthritis.
8.Knee surgery.
9.Patients with high cholesterol levels.
9. Cardiopulmonary or cardiovascular problems.
10. A recent history of vestibular disorder, inner ear infection with associated balance.
11.Coordination problems.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)Cotinine and serotonin serum level will be tested laboratory using Blood samples.<br>2)Bilateral Knee extensors peripheral fatigue and bilateral Knee proprioception will be measured using Biodex Isokinetic dynamometer.<br>

Secondary Outcome Measures

Name	Time	Method
Effects of serum cotinine level on knee proprioception