Role of perinatal factors in formation of neurologic and somatic status at an early age of preterm infants

Not Applicable

Recruiting

• Conditions: Prematurity; Endothelial function, intracellular adhesion and apopthosis function in perinatal period; Public Health - Health service research; Reproductive Health and Childbirth - Complications of newborn; Neurological - Studies of the normal brain and nervous system

• Registration Number: ACTRN12612000342819
• Lead Sponsor: Azerbaijan Medical Unversity

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-03-26
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Preterm infant
Parents must agree to assessment requirements (biomarker analysing, DENVER II development test) of the study

Exclusion Criteria

major congenital anomalies

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Detecting the correlations between the level of organ and endothelial disfunction markers (detected in umbilical cord blood and peripheral blood of infants in early neonatal period) and illness appearing till 3 year of age on the base of statistical analysis.[at three years after randomisation]

Secondary Outcome Measures

Name	Time	Method
Prognosing early age changes of neuro-somatic status on the background of detected perinatal risk factors and performing follow up control. Perinatal risk factors will be assesed on the base of maternal and neonatal health status referring to investigation history of every infant. The severity of hypoxic ischemic encephalopathy will be based on the Levene classification. Cranial ultrasound will be performed for all infants at the 2-nd and 6-th days of life with 5 and 7, 5 MHz vector transducers. The neurological assessment will be performed according to Dubowitz/Ballard scale during neonatal period. Behavior, motor and sensor development from 1-st month till 3-nd year of life will be assesed by DENVER II test.[at three years after randomisation]