Energy metabolism of working muscles in patients after burn injury

Completed

• Conditions: burn wounds; 10040790

• Registration Number: NL-OMON42597
• Lead Sponsor: Martini Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 6

Inclusion Criteria

Patients aged 18-65 years, admitted to the Martini Hospital Burn Center with burns covering 15% or more of total body surface area (TBSA).

Exclusion Criteria

- only facial burns
- contraindications for MRI studies
- inability to perform bicycle exercise
- contra-indications for high intensity exercise testing
- known coronary artery disease, positive history for angina pectoris, or changes on ECG suggestive of previous ischaemia without a negative stress test
- intercurrent illness which may influence exercise tolerance (anaemia, musculoskeletal injury, or other undiagnosed illness under investigation)
- pre-existing insulin-dependent diabetes mellitus
- pregnancy or current breastfeeding, or females not taking the oral contraceptive pill
- any other cause which in the opinion of the investigators, may affect the volunteers ability to participate in the study
- insufficient proficiency in Dutch or English to the extent that clear communication is not possible
- loss of, or an inability to give informed consent

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>In vivo intramuscular steady-state levels of inorganic phosphate (Pi),<br /><br>phoshocreatine (PCr), and pH at rest versus (prolonged) exercise, and the<br /><br>dynamics of Pi, PCr and pH recovery following exercise.</p><br>