Study of Vitamin D and Statins on Vascular Function in hypertensive patients
Phase 2
Recruiting
- Conditions
- Cardiac and renal hypertensive disease, non specifiedI13.9
- Registration Number
- RBR-2zx53z
- Lead Sponsor
- nifesp - Universidade Federal de São Paulo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Volunteers with essential hypertension, without hypertension related organ damage. Between 18 and 75 years old.
Exclusion Criteria
Patients previously with: Diabetes mellitus; Autoimunne disease; Neurologic Degenerative disease; Calcium or phosphate metabolism disease; Clinical need of lipid lowering drug prescription. Beside these: Patients who refuse to sign in voluntary consent letter; Patients with severe Hypertension (Sys > 180mmHg / Dias >110mmHg); Patients with hypertensive organ related damage or patients with secundary hypertension diagnosis.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reduction of the value of the ADMA (Asymmetric Dimethyl Arginine ) compared to the baseline value (pre-treatment) of about 30% as measured by the HPLC method (high perfomance liquid chromatography)
- Secondary Outcome Measures
Name Time Method Reduction of the expression of inflammatory markers - Tumor necrosis factor in about 15% in cultures of cells treated with the serum of the patients of each intervention arm measured by real time PCR;Reduction of Angiotensin 2 expression by about 15% in cultures of cells treated with patient serum from each intervention arm by ELISA protocol