The effect of olive leaf extract on blood pressure in overweight prehypertensives
Not Applicable
- Conditions
- Cardiovascular - HypertensionHypertension
- Registration Number
- ACTRN12613000180718
- Lead Sponsor
- Massey University, Institute of Food, Nutrition and Human Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- Male
- Target Recruitment
- 60
Inclusion Criteria
Men
18-65 years;
Non-smokers;
Prepared to consume olive leaf extract liquid
Systolic blood pressure 121-139 mmHg and diastolic blood pressure 81-89 mmHg
Body mass index (BMI) between 25-30 kg/m2 or waist >102 cm
Exclusion Criteria
Smokers
Using blood pressure, lipid lowering, thyroid disorder, blood clotting medication
Using supplements or functional foods that will affect lipid concentrations (e.g. sterol enriched spreads)
Chronic disease e.g. CHD, diabetes, cancer, digestive disorders
Individuals who are unwilling to refrain from consuming olive containing products for the duration of the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood pressure measured via 24 hour ambulatory blood pressure monitors[6 weeks ]
- Secondary Outcome Measures
Name Time Method Vascular function assessed by pulse wave velocity (PWV) [6 weeks];Lipid profile measured via serum assay[6 weeks];Inflammatory cytokines measured via plasma assay[6 weeks];Fructosamine measured via plasma assay[6 weeks];Glucose measured via plasma assay[6 weeks];Nitric oxide measured via plasma assay[6 weeks];Insulin measured via plasma assay[6 weeks];Haemostatic factors (D-dimer, PAI-1 ag, von Willebrand factor, prothrombin F1+2, factor VIII) measured via plasma assay[6 weeks];oxidised LDL measured via plasma assay[6 weeks];Obesity markers (adiponectin, CCL-2, complement factor D, CRP, IL-6, IL-10, leptin, resistin, serpin E1 and TNF-a) measured via plasma assay[6 weeks]