Het effect van drop op de bloeddruk, cortisol/cortison ratio en elektroliete
Recruiting
- Conditions
- Hypertension, Licorice, Pseudohyperaldosteronism, Hypokalemia
- Registration Number
- NL-OMON26713
- Lead Sponsor
- one
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Willing and able to participate in the study protocol
- Written informed consent
Exclusion Criteria
- Allergy to one of the ingredients of licorice
- Office blood pressure >140/90 mmHg
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Systolic daytime ambulatory blood pressure
- Secondary Outcome Measures
Name Time Method - Diastolic daytime ambulatory blood pressure, systolic and diastolic night-time blood pressure and systolic and diastolic 24-hour ambulatory blood pressure<br /><br>- Cortisol/cortisone ratio, potassium, sodium and aldosterone excretion in 24h urine collection<br /><br>- Concentrations of plasma potassium, sodium, eGFR, creatinine, aldosterone and plasma renin activity<br /><br>- Individual susceptibility, participants with significant changes will be considered by investigating the existence of genetic single nucleotide polymorphisms<br /><br>- Heart rate (daytime, night-time and 24 hour)<br /><br>- Changes in body weight