Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

Completed

• Conditions: Single-nucleotide Polymorphism (SNP) for Glaucoma
• Interventions: Genetic: SNP analysis of the DNA

• Registration Number: NCT01025024
• Lead Sponsor: Chungnam National University

Brief Summary

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Detailed Description

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Study Timeline

• Study Start: 2007-01
• Primary Completion: 2009-10
• Study Completion: 2009-11
• Status Verified: 2009-12
• Study First Submitted: 2009-12-02
• Study First Submitted QC: 2009-12-02
• Last Update Submitted: 2009-12-02
• Study First Posted: 2009-12-03
• Last Update Posted: 2009-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1224

Inclusion Criteria

• Clinical diagnosis of primary open angle glaucoma

Exclusion Criteria

• Primary open angle glaucoma combined with congenital ocular disease
• Primary open angel glaucoma combined with other ocular disease
• Significant systemic disease other than systemic hypertension and diabetes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
POAG group	SNP analysis of the DNA	Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect
Normal control	SNP analysis of the DNA	Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease

Primary Outcome Measures

Name	Time	Method
genotyping for the SNP associated with primary open angle glaucoma	one year

Secondary Outcome Measures

Name	Time	Method
genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns	one year

Trial Locations

Locations (1)

Chungnam National University Hospital; 🇰🇷 Daejeon, Korea, Republic of