Risk Factors for Postpartum Psychosis

Completed

• Conditions: Postpartum Period; Psychosis

• Registration Number: NCT00872313
• Lead Sponsor: Nanjing Medical University

Brief Summary

A range of psychological disorders occur in women in the postpartum period. These include "the blues", which occurs in the first days after birth and which is very common and self-limiting; severe psychoses often associated with mania or bipolar illness, occurring in the first weeks after birth; and mild to moderate depression, occurring weeks to months after birth. Studies have been done focused on postpartum psychosis using a retrospective investigation, which gave only a limited material on the prevalence of psychological disorders in postpartum women. The investigators hypothesized that different pathways to psychosis function as the risk factors which may be overlapped, truly independent, mediating, or moderating, in new mothers who are at high risk and/or during the early period of delivery. In addition, the investigators purposed that the temporal sequence of biological, social and demographic variables are also the potential factors contributing to the development of postpartum psychosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-02
• Study First Submitted: 2009-03-30
• Study First Submitted QC: 2009-03-30
• Study First Posted: 2009-03-31
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-11
• Last Update Posted: 2014-01-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 4000

Inclusion Criteria

• Pregnant women
• Chinese

Exclusion Criteria

• Age < 18 years or > 50 years
• Gestational age < 32 weeks

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of psychoses	3 months and 6 months postpartum

Secondary Outcome Measures

Name	Time	Method
Antepartum economic level	One year before labor and delivery (recorded by antepartum communication)
Antepartum social status	One year before labor and delivery (recorded by antepartum communication)
Antepartum psychological level	1 day before birth
Intrapartum complications	1 day after birth
Baby characteristics	One minute, 5min, 15min after baby was born
Maternal characteristics	One day after birth
Medical caregiver characteristics	One day before and after the labor completion
Parturient family characteristics	One week before labor and delivery, recorded by investigators through patients' antepartum communication
Intrapartum medical procedures	One day after birth

Trial Locations

Locations (1)

Nanjing Maternal and Child Health Care Hospital; 🇨🇳 Nanjing, Jiangsu, China