Mechanisms of albuminuria in diabetes: reversal of injury to the glycocalyx by the ace-inhibitor lisinopril
- Conditions
- Diabetes Mellitus, microalbuminuria, glycocalyx, ACE-inhibitor
- Registration Number
- NL-OMON23821
- Lead Sponsor
- Academic Medical Center (AMC), Department of Internal Medicine
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
1. Caucasian males
2. Diagnosis of type 1 diabetes according to ADA criteria
Exclusion Criteria
1. Hypertension as defined by systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg or use of antihypertensive drugs
2. Previous use of RAS inhibitor2
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of this study is the change in microvascular glycocalyx thickness after treatment.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are changes in oxidative stress, inflammation, coagulation microalbuminuria and glomerular charge selectivity.