Mechanisms of albuminuria in diabetes; reversal of injury to the glycocalyx by the ACE inhibitor lisinopril - MADRIGA
- Conditions
- Diabetes mellitusMedDRA version: 9.1Level: LLTClassification code 10045228Term: Type I diabetes mellitus
- Registration Number
- EUCTR2008-002610-21-NL
- Lead Sponsor
- Academic Medical Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Authorised-recruitment may be ongoing or finished
- Sex
- Male
- Target Recruitment
- Not specified
Inclusion Criteria
Caucasian males
Diagnosis of type 1 diabetes
Urinary alb/creat ratio < 3.5 mg/mmol, without antiproteinuric treatment
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Exclusion Criteria
Hypertension (RR syst > 140 mmHg, RR diast. > 90 mmHg)
Previous use of RAS inhibitors
Smoking
Primary dyslipidemia's
Use of statins during the six weeks before visit 1
Use of antioxidants in the two weeks prior to visit 1
Angioedema in medical history
Hypersensitivity to ACE inhibitors
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method