Diabetes type 2 and the role of macroalbuminuria; a diagnostic tool for vascular ageing with 18F-NaF PET/CT imaging.
- Conditions
- Accelerated vascular ageingType 2 diabetesDiabetic nephropathy/macroalbuminuria
- Registration Number
- NL-OMON22887
- Lead Sponsor
- niversity Medical Center Groningen
- Brief Summary
one yet.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Inclusion criteria T2D patients:
•Men and women, age above 18 years
Exclusion Criteria
Exclusion criteria T2D patients:
•Type 1 diabetes
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To investigate whether arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected) are increased in patients with T2D with preserved renal function who have macroalbuminuria as compared to patients with normoalbuminuria.
- Secondary Outcome Measures
Name Time Method 1.To investigate whether arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected) are associated with vascular stiffness (assessed by PWV).<br /><br>2.To investigate whether arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected) are associated with markers of the metabolic syndrome, including adipose tissue volumes (visceral and subcutaneous), adipokines, insulin resistance index (HOMA-IR), and clinical components (HbA1c, fasting glucose, lipid metabolism, and blood pressure).<br /><br>3.To investigate whether arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected) are associated with markers of the calcium phosphate metabolism <br /><br>4.To investigate which of the above mentioned factors (i.e. macroalbuminuria, metabolic syndrome, calcium phosphate metabolism, and kidney function) are independent determinants of arterial microcalcification (18F-NaF-PET detected) and macrocalcification (CT detected).<br>