The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided Intubation

Not Applicable

Completed

• Conditions: Lumbar Spinal Stenosis
• Interventions: Drug: Oxygen

• Registration Number: NCT02625194
• Lead Sponsor: Yonsei University

Brief Summary

This study investigate the utility of continuous oxygen insufflation during fiberoptic bronchoscope-guided intubation.

One group receives oxygen via suction channel of fiberoptic bronchoscope during intubation.

The other group does not receive oxygen during fiberoptic bronchoscope-guided intubation.

Then, the velocity of deoxygenation difference of PaO2(baseline

Detailed Description

Fiberoptic bronchoscope-guided intubation is a gold standard for intubation of a patient with anticipating difficult airway. This technique takes several minutes without oxygen supply, which results in hypoxia when it prolonged. If continuous supply of oxygen during procedure improve the oxygenation, we can reduce the risk of hypoxemia and increase the safety margin during procedure.

Study Timeline

• Study First Submitted: 2015-11-25
• Study First Submitted QC: 2015-12-06
• Study First Posted: 2015-12-09
• Study Start: 2016-01-01
• Primary Completion: 2017-09-04
• Study Completion: 2017-09-04
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-08
• Last Update Posted: 2019-07-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• patients who have surgery under general oral endotracheal anesthesia with invasive arterial blood pressure monitoring

Exclusion Criteria

• history of lung disease
• abnormality in chest x-ray
• anticipating difficult intubation
• pregnant women
• who is unable to understand and agree the consent form

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Oxygen	Oxygen	Oxygen is supplied through suction port in bronchoscope during bronchoscope-guided intubation.

Primary Outcome Measures

Name	Time	Method
Velocity of PaO2 decrease	from mask removal to 1st manual ventilation after intubation, up to 5 minute	After administration of anesthetic agents and manual ventilation of 5 minutes, arterial blood sampling is collected. Then bronchoscope-guided intubation performed and arterial blood sample is collected immediately after the intubation completed. Time for intubation (between 1st and 2nd blood sample) is recorded. The difference of PaO2(before \& after intubation) is divided by the time taking for intubation.

Secondary Outcome Measures

Name	Time	Method
visual field	throughout the intubation with bronchoscope, upto 5 minute	Visual field is evaluated by the blinded observer. It is evaluated as followed;excellent, good, poor, impossible
success of intubation	300 sec after the beginning of intubation	After 1st trial of intubation, the success of intubation is recorded. If it takes more than 300 sec, it will be considered failure.
pH	1. 5 minutes after manual ventilation / 2.right before 1st manual ventilation after intubation, up to 5 minute	arterial blood samples are collected before and after intubation.
PaO2	1. 5 minutes after manual ventilation / 2.right before 1st manual ventilation after intubation, up to 5 minute	arterial blood samples are collected before and after intubation.
PaCO2	1. 5 minutes after manual ventilation / 2.right before 1st manual ventilation after intubation, up to 5 minute	arterial blood samples are collected before and after intubation.

Trial Locations

Locations (1)

Gangnam severance hospital; 🇰🇷 Seoul, Korea, Republic of