Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia
Phase 4
- Conditions
- Preeclampsia
- Registration Number
- NCT00117546
- Lead Sponsor
- Radboud University Medical Center
- Brief Summary
A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the researchers will test that effect on the total cardiovascular balance.
- Detailed Description
This is a randomized double-blind placebo controlled cross-over study in formerly preeclamptic women with a contracted plasma volume. The researchers will test the effect of methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history of preeclampsia and healthy controls.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 35
Inclusion Criteria
- Primiparous
- History of preeclampsia
- Low plasma volume
Exclusion Criteria
- Thrombophilia
- Hypertension
- Auto-immune disorder
- Insulin dependent diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method normalized plasma volume 1 month
- Secondary Outcome Measures
Name Time Method increased orthostatic tolerance 1 month normalized cardiovascular balance 1 month venous capacitance 1 month
Trial Locations
- Locations (1)
Radboud University Nijmegen Medical Center
🇳🇱Nijmegen, Netherlands