NCT00117546Unknown4 期
Cardiovascular Performance and Autonomic Reactivity in Formerly Preeclamptic Women With a Contracted Plasma Volume (CAPACITY Trial)
适应症
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- normalized plasma volume
研究概览
简要总结
A history of preeclampsia is associated with a low plasma volume and higher sympathetic activity. Methyldopa will suppress sympathetic activity to normal values. In this study, the researchers will test that effect on the total cardiovascular balance.
详细描述
This is a randomized double-blind placebo controlled cross-over study in formerly preeclamptic women with a contracted plasma volume. The researchers will test the effect of methyldopa on the cardiovascular balance and orthostatic tolerance in women with a history of preeclampsia and healthy controls.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Double
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Primiparous
- •History of preeclampsia
- •Low plasma volume
排除标准
- •Thrombophilia
- •Hypertension
- •Auto-immune disorder
- •Insulin dependent diabetes mellitus
结局指标
主要结局
normalized plasma volume
时间窗: 1 month
次要结局
- increased orthostatic tolerance(1 month)
- normalized cardiovascular balance(1 month)
- venous capacitance(1 month)
研究者
研究点 (1)
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