KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease
- Conditions
- Chronic Kidney Disease(CKD)
- Registration Number
- NCT02165878
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) is a nation-wide, ten-year longitudinal cohort study, launched in 2011. The aim of the study is to assess the characteristics and risk factors of progression and complications of CKD of Korea. Pediatric sub-cohort of KNOW-CKD is planned to enroll 450 children with CKD, stage I to V (pre-dialysis).
- Detailed Description
Seven major pediatric nephrology centers of Korea enrolled children younger than 20 years who had CKD. Medical history taking, questionaire assessment of socio-economic status, anthropometric measurement, and clinical assessment using laboratory and imaging tests were done. Outcome is development of LV hypertrophy or hypertension, growth, neuropsychological status, behavioral status, kidney growth, and quality of life.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 458
- Age: < 20 yr
- CKD stage 1 through 5 of KDIGO guideline
- predialysis
- Dialysis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method eGFR 10 years eGFR in mL/min/1.73 m2
- Secondary Outcome Measures
Name Time Method Metabolic bone disease 10 years Bone Dexametry in z score
Anemia 10 years Anemia in g/dL
Growth 10 years Height in z score
Development of cardiovascular disease 10 years Hypertrophy in g/m2
Health-related quality of life (HRQOL) 10 years PedsQL 4.0 Generic Core Scale Module (Mapi Research Trust, on behalf of Dr James W. Varni, copyright owner of PedsQL™)
Cognitive skills and emotional development 10 years K-WAIS score
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of