KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 458
- 试验地点
- 1
- 主要终点
- eGFR
研究概览
简要总结
KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) is a nation-wide, ten-year longitudinal cohort study, launched in 2011. The aim of the study is to assess the characteristics and risk factors of progression and complications of CKD of Korea. Pediatric sub-cohort of KNOW-CKD is planned to enroll 450 children with CKD, stage I to V (pre-dialysis).
详细描述
Seven major pediatric nephrology centers of Korea enrolled children younger than 20 years who had CKD. Medical history taking, questionaire assessment of socio-economic status, anthropometric measurement, and clinical assessment using laboratory and imaging tests were done. Outcome is development of LV hypertrophy or hypertension, growth, neuropsychological status, behavioral status, kidney growth, and quality of life.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: < 20 yr
- •CKD stage 1 through 5 of KDIGO guideline
- •predialysis
排除标准
- 未提供
结局指标
主要结局
eGFR
时间窗: 10 years
eGFR in mL/min/1.73 m2
次要结局
- Metabolic bone disease(10 years)
- Anemia(10 years)
- Growth(10 years)
- Development of cardiovascular disease(10 years)
- Health-related quality of life (HRQOL)(10 years)
- Cognitive skills and emotional development(10 years)
研究者
Il Soo Ha
Professor
Seoul National University Hospital