Epigenetic changes associated with ECT treatment
Completed
- Conditions
- cognitieve en aandachtsstoornissen en -afwijkingendepressionmemory complaints10027946
- Registration Number
- NL-OMON33354
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
depressive disorder and eligible for ECT treatment
Exclusion Criteria
• age < 18 years and age >65 jaar
• major medical conditions that may interfere with the study procedures: cancer, cerebrovascular disorders, organic psychiatric syndromes, active drug abuse, mental retardation, dementia and other neurodegenerative disorders. Psychopathology will be assesses by a psychiatric interview.
• Illiteracy
• any condition which in the opinion of the (co-) investigator might interfere with the evaluation of the study objectives
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. association between the epigenetic changes like DNA-methylation and histone<br /><br>modifications of certain genes in blood lymphocytes and the cognitive side<br /><br>effects of ECT treatment<br /><br>2. association between the epigenetic changes like DNA-methylation and histone<br /><br>modifications of certain genes in blood lymphocytes and the response to ECT.<br /><br>The endpoint of the study will be 6 weeks after cessation of the ECT treatment. </p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>