THE EFFECT OF ELECTRO CONVULSIVE THERAPY (ECT) ON RECONSOLIDATION OF HUMAN LONG-TERM MEMORY

Recruiting

Conditions: Anxiety disorders
Depression
10002861

Registration Number: NL-OMON32461

Lead Sponsor: Radboud Universiteit Nijmegen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

- Gender: male and female
- Age: >18 years
- Patients undergoing ECT for unipolar major depressive disorder with and without psychotic features.
- Patients are medication free or under a stable therapy with antidepressants
- Normal or corrected-to-normal vision
- Normal or corrected-to-normal hearing
- Willingness and ability to give written informed consent and willingness and ability to understand the nature and content, to participate and to comply with the study requirements.

Exclusion Criteria

- Age: < 18
- Medical or surgical history that in the investigator*s view may significantly affect the outcome of the trial; such as presence of current or past relevant somatic or neurological disorder.
- Co-morbid diagnosis of bipolar depressions, schizophrenia, or substance dependence disorders.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Reactivation: Difference in memory for reactivated vs non-reactivated<br /><br>material.<br /><br>- Sustained memory disruption: Difference in memory for reactivated vs non<br /><br>reactivated material after a delay period controlling for spontaneous recovery.<br /><br>- Time-dependency: Difference in memory for reactivated vs non-reactivated<br /><br>material immediately after ECT and 24h after ECT.<br /><br>- Secondary encoding: Difference in reactivated memory vs non-reactivated<br /><br>memory post- and pre-ECT</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Emotional memory: Difference in memory for emotional vs neutral material.<br /><br>- General effect of ECT: Difference in general memory pre- and post-ECT.</p><br>