A study on the therapeutic effect of modified electroconvulsive therapy in refractory schizophrenia

Not Applicable

Completed

• Conditions: Treatment-resistant schizophrenia; Mental and Behavioural Disorders

• Registration Number: ISRCTN96331501
• Lead Sponsor: Wuhan Wudong Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2020-03-01
• Study Start: 2024-03-11
• Last Update Posted: 25 March 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 108

Inclusion Criteria

1. Aged >18 years old
2. With complete medical records
3. With Positive and Negative Syndrome Scale (PANSS) scores for both positive and negative symptoms >60 points
4. With a clinical diagnosis of TRS
5. Who had had TRS for >5 years
6. Who had had previous treatment with 2 or more antipsychotic drugs of different chemical structure, each at a sufficient dosage, with no significant improvement after continuous treatment for more than 2 months
7. Those who did not show drug intolerance or maladaptation during the course of this study

Exclusion Criteria

Does not meet inclusion criteria

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of positive and negative symptoms assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and 2 months after treatment

Secondary Outcome Measures

Name	Time	Method
Measured before treatment and 2 months after treatment:<br>1. Anxiety and depression measured using the Hamilton Anxiety Rating Scale (HAMA) and the Hamilton Depression Rating Scale (HAMD)<br>2. Severity of trauma exposure measured using the Traumatic Exposure Severity Scale (TESS)<br>3. Severity of disease measured using the Brief Psychiatric Rating Scale (BPRS)<br>4. Memory measured using the Wechsler Memory Scale (WMS)