ECT-induced connectivity mechanisms in treatment resistant depressio

Recruiting

• Conditions: Depression; Major Depressive Disorder; 10027946

• Registration Number: NL-OMON52975
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

• Males and females between 18-70 years of age
• First or recurrent episode of unipolar major depressive disorder, with and
without psychotic features (as defined by DSM-IV-TR)
• Treatment resistance for at least two antidepressants

Exclusion Criteria

• ECT within one year prior to the current course
• Use of benzodiazepines within 24 hours before ECT
• Presence of a current or past relevant somatic disorder
• Presence of comorbid bipolar disorder, schizophrenia or substance abuse
disorder
• MRI-related exclusion criteria (i.e. claustrophobia, pregnancy, internal
metal objects, etc.)
• ECT-related exclusion criteria (recent cerebrovascular disease or brain
surgery, recent cardiac arrest, unstable angina pectoris (NYHA IV),
pheochromocytoma)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- changes in functional connectivity in resting state networks as a function of<br /><br>treatment (response)<br /><br>- changes in VTA-related BOLD-signals and habenula-VTA connectivity coding for<br /><br>Temporal Difference Errors in reward/punishment-related learning as a function<br /><br>of treatment (response)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- changes in structural brain characteristics (cortical thickness, subcortical<br /><br>volumes) as a function of treatment (response)</p><br>