Evaluation of the therapeutic effects of Convalescent Plasma (CP) of recovered people from Covid-19 in improving clinical and laboratory symptoms of hospitalized patients

Semnan University of Medical Sciences0 个研究点目标入组 12 人开始时间: 待定最近更新: 2020年5月18日

适应症

试验速览

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•(As a plasma donor): Complete resolution of COVID-19 disease symptoms at least 14 days prior to donation.
•(As a plasma donor): Donors do not have a history of blood or blood product transfusion
•(As a plasma donor): COVID-19 neutralizing antibody titers be greater than 1:320 (If possibly checked)
•(As a plasma donor): The donor's age be between 25 and 55 years old
•(As a plasma donor): Negative results for COVID-19 by PCR
•(As a plasma donor): Be in suitable general health condition for plasmapheresis
•(As a plasma recipient): Patients admitted to the ICU who is receipt of mechanical invasive or non-invasive ventilation, partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300mmHg (93%). Current receipt of intravenous vasoactive medications to maintain mean arterial pressure >65 mmHg
•(As a plasma recipient): Respiratory frequency = 30/min
•(As a plasma recipient): Laboratory-confirmed COVID-19 infection (by real time PCR).

•(As a plasma recipient): Negative real-time PCR from respiratory secretions or blood within 48 h prior to CP transfusion
•(As a plasma recipient): History of allergic reaction to blood or plasma products
•(As a plasma recipient): Known IgA deficiency

发起方

Semnan University of Medical Sciences