NL-OMON54674招募中不适用
The yield of a yearly surveillance program for the early detection of pancreatic cancer and its precursor lesions in high-risk individuals - Early detection of pancreatic cancer in high-risk individuals
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 700
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Eligible are individuals who, after evaluation by a clinical geneticist, have
- •an estimated >10-fold increased risk of developing pancreatic cancer, this
- •(1) Carriers of CDKN2A gene mutations (excl. mutation in exon 1b), regardless
- •of the family history of pancreatic cancer
- •(2) Peutz-Jeghers Syndrome patients (diagnosis based on a proven LKB1 gene
- •mutation and/or clinical diagnosis), regardless of the family history of
- •pancreatic cancer
- •(3) Carriers of gene mutations in BRCA1, BRCA2, PALB2, ATM, p53, or Mismatch
- •Repair Gene with a family history of pancreatic cancer in at least 2 family
- •members (at least 1 PA proven, and at least 1 also a mutation carrier)
排除标准
- •1) Personal history of pancreatic cancer
- •(2) Age younger than 18 years
- •(3) Individuals unable to provide informed consent either due to mental
- •retardation or language barrier
- •(4) Severe medical illness: WHO 1 to 5
- •(5) PRSS1 gene mutation carrier
- •(6) Contra-indication for EUS, due to anatomic abnormalities/surgery or
- •patients whish.
- •Individuals who already participate in the study with MRI-only (no EUS) will be
- •excluded if they
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