CRP and PCT as Predictors of Sepsis Cause

Completed

• Conditions: Gram-Positive Bacteremia; Gram-negative Bacteremia; Sepsis
• Interventions: Diagnostic Test: PCT levels; Diagnostic Test: CRP levels; Diagnostic Test: White blood cell count; Diagnostic Test: Platelet count

• Registration Number: NCT05605275
• Lead Sponsor: Osijek University Hospital

Brief Summary

The aim of this retrospective study is to determine the predictive role of serum level of procalcitonin (PCT) and c-reactive protein (CRP) in determining the causative agent of sepsis in surgical intensive care unit (ICU) patients. The main question it aims to answer is: what serum level of PCT and CRP is predictive of gram+ and gram- sepsis in patients with positive blood cultures in the surgical ICU. The study will be retrospective and will include all patients with positive blood cultures who were hospitalized in the surgical ICU of University Hospital Osijek in the period from January 2019 to May 2022.

Detailed Description

PCT is a good biochemical marker of severe bacterial infection. Numerous studies have confirmed its role in the diagnosis of sepsis, especially sepsis with positive blood cultures. This retrospective study will include septic patients who were hospitalised in the surgical ICU between January 2019 and May 2022, and who had at least one positive blood culture. The values of PCT, CRP, white blood cells count and platelets count, as well as the overall outcome of the treatment, will be recorded for the patients included in the research. The aim of the research is to examine the differences in the level of PCT, CRP, white blood cells count and platelets count between patients with gram+ and gram- blood cultures. Also, the predictive value of PCT and CRP in differentiating gram+ from gram- hem will be examined.

Study Timeline

• Study Start: 2022-01-05
• Status Verified: 2022-10
• Study First Submitted: 2022-10-30
• Study First Submitted QC: 2022-10-30
• Study First Posted: 2022-11-04
• Primary Completion: 2023-07-10
• Study Completion: 2023-07-10
• Last Update Submitted: 2023-07-14
• Last Update Posted: 2023-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

• hospitalisation in surgical ICU
• diagnosis of sepsis
• gram+ blood culture isolate
• gram- blood culture isolate

Exclusion Criteria

• younger of 18 years old

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Gram negative	White blood cell count	Patients who had at least one blood culture with a gram- isolate during hospitalisation in the surgical ICU
Gram negative	PCT levels	Patients who had at least one blood culture with a gram- isolate during hospitalisation in the surgical ICU
Gram negative	Platelet count	Patients who had at least one blood culture with a gram- isolate during hospitalisation in the surgical ICU
Gram negative	CRP levels	Patients who had at least one blood culture with a gram- isolate during hospitalisation in the surgical ICU
Gram positive	PCT levels	Patients who had at least one blood culture with a gram+ isolate during hospitalisation in the surgical ICU
Gram positive	CRP levels	Patients who had at least one blood culture with a gram+ isolate during hospitalisation in the surgical ICU
Gram positive	White blood cell count	Patients who had at least one blood culture with a gram+ isolate during hospitalisation in the surgical ICU
Gram positive	Platelet count	Patients who had at least one blood culture with a gram+ isolate during hospitalisation in the surgical ICU

Primary Outcome Measures

Name	Time	Method
Predictive level of PCT	4 days	Predictive serum level of PCT in differentiating gram+ from gram- blood culture
Predictive level of CRP	4 days	Predictive serum level of CRP in differentiating gram+ from gram- blood culture

Secondary Outcome Measures

Name	Time	Method
White blood cells count	4 days	Test for differences in WBC count between patients with gram+ and gram- blood cultures
PCT levels and outcome	4 days	To examine differences in serum PCT levels between patients who survived and those who died
Platelets count	4 days	Test for differences in platelets count between patients with gram+ and gram- blood cultures
CRP levels and outcome	4 days	To examine differences in serum CRP levels between patients who survived and those who died

Trial Locations

Locations (1)

University Hospital Osijek; 🇭🇷 Osijek, Croatia