Measurement of gut permeability in healthy people with a different metabolic profile.
- Conditions
- Metabolic health (waist circumference, BMI, fasting glucose, HbA1c, LDL cholesterol, HDL cholesterol, total cholesterol, total triglycerides, ALT, GGT and hsCRP)
- Registration Number
- NL-OMON20611
- Lead Sponsor
- Stichting Dienst Landbouwkundig OnderzoekWageningen UR Food & Biobased ResearchConsumer Science & HealthBornse Weilanden 96708 WG Wageningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
Apparently healthy
-Age range between 20-70 years old (the two groups should be age balanced as much as possible)
Exclusion Criteria
-Gastrointestinal disorders (stomach ulcer, ulcerative colitis, Crohn¡¯s disease, celiac disease)
-History of gastrointestinal surgery
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study parameter is gut permeability assessed by a MS permeability test. In this test, gut permeability is reflected by the urinary excretion levels of sucrose, lactulose, rhamnose, sucralose and erythritol. These sugars are measured in 3 urine fractions that are collected during 24 hours after consumption of a MS mix solution containing these five sugars. Gut permeability will be compared between metabolic healthier and metabolic unhealthier subjects.
- Secondary Outcome Measures
Name Time Method Secondary parameters are fasting state levels of leaky gut biomarkers (LPS, LBP, sCD14, zonulin and leptin) and metabolic health parameters (waist, BMI, HbA1c, glucose, LDL cholesterol, HDL cholesterol, total cholesterol, total triglycerides, ALT, GGT and CRP). These parameters will be compared between metabolic healthier and metabolic unhealthier subjects and correlated with gut permeability as assessed by the MS permeability test.