Efficacy of Dexmedetomidine VS Magnesium Sulphate With Bupivacaine in Erector Spinae Block for Thoracotomy Pain

Not Applicable

Recruiting

• Conditions: Analgesia
• Interventions: Drug: Bupivacaine; Drug: Bupivacaine + Magnesium; Drug: Bupivacaine + Dexmedetomidine

• Registration Number: NCT05851768
• Lead Sponsor: National Cancer Institute, Egypt

Brief Summary

Postoperative pain management is considered an integral part of perioperative care in patients undergoing thoracotomy. In order to reduce these complications, multiple regional techniques have been developed for thoracotomy including Intercostal nerve block, Erectospinae plane block and serratus block. Multiple adjuvants have been used in regional analgesia including adrenaline,clonidine,magnesium sulphate,dexmedatomidine and opoids.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-05-01
• Study First Submitted QC: 2023-05-01
• Study First Posted: 2023-05-10
• Study Start: 2023-05-15
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-18
• Last Update Posted: 2024-02-20
• Primary Completion: 2024-03-25
• Study Completion: 2024-04-27

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age from 18 to 65 years.
• Male and female sexes.
• ASA I-II.,III
• Cancer patients undergoing thoracotomy incisions
• Body mass index (BMI) from 18.5 to 30 kg/m2

Exclusion Criteria

• Patient refusal
• Known allergy to any of the used drugs
• Low platelet count, any coagulation defect

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Erector spinae plane block with 0.25% bupivacaine	Bupivacaine	Patients will receive ultrasound guided ESPB with 0.25% bupivacaine
Erector spinae plane block with 0.25% bupivacaine and Magnesium	Bupivacaine + Magnesium	Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and magnesium
Erector spinae plane block with 0.25% bupivacaine and Dexmedetomidine	Bupivacaine + Dexmedetomidine	Patients will receive ultrasound guided ESPB with 0.25% bupivacaine and dexmedetomidine

Primary Outcome Measures

Name	Time	Method
Total postoperative morphine consumption	First 24 hours postoperatively	Total dose of morphine needed postoperatively in the first 24 h

Secondary Outcome Measures

Name	Time	Method
Time to first postoperative rescue analgesia.	First 24 hours postoperatively	Time to first postoperative rescue analgesia.

Trial Locations

Locations (1)

Walaa Y Elsabeeny; 🇪🇬 Cairo, Egypt