Evaluating Modulation Effects of Temporal Interference Using SEEG
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Deep Brain Stimulation
- Sponsor
- Xuanwu Hospital, Beijing
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Electrophysiological changes
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with drug-resistant epilepsy.
Detailed Description
Temporal Interference (TI) technology is a novel non-invasive method for deep brain stimulation (DBS). By generating an overlapping electric field from safe currents, TI creates focused stimulation in targeted deep brain areas. This approach allows for the exploration of deep brain nuclei functions and has the potential to serve as a non-invasive alternative to traditional invasive DBS for clinical treatments. Stereoelectroencephalography (SEEG) is a method for recording electrical activity from deep brain structures using implanted depth electrodes to provide a three-dimensional view of neuronal activity. This study aims to investigate the electrophysiological mechanisms of temporal interference (TI) deep brain stimulation by including patients aged 14-60 with implanted intracranial electrodes. During and after TI stimulation, electrophysiological and clinical data will be recorded. Clinical, imaging, and electrophysiological data will be analyzed and processed to advance understanding of TI's effects in deep brain stimulation.
Investigators
Liankun_Ren
Professor
Xuanwu Hospital, Beijing
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of drug-resistant epilepsy;
- •No severe systemic diseases;
- •Implantation of stereotactic electrodes;
- •Agreement to participate in this study and signs the informed consent form.
Exclusion Criteria
- •Hematoma at the scalp electrode site or fluid accumulation under the electrode after intracranial electrode placement.
Outcomes
Primary Outcomes
Electrophysiological changes
Time Frame: During the trial(up to 3 hours for each subject)
Electrophysiological waveform changes recorded by stereoelectroencephalography (SEEG) before, during, and after TI stimulation.
Secondary Outcomes
- Patient's subjective feelings and symptoms(During the trial(up to 3 hours for each subject))