Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot Study)
- Conditions
- Cocaine Use Disorder
- Interventions
- Device: iTBS to dmPFCDevice: Sham iTBS
- Registration Number
- NCT05631548
- Brief Summary
The purpose of this study is to assess the effects of active intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal cortex (dmPFC) on electroencephalogram (EEG) measures of reward sensitivity and cue reactivity and cocaine craving in cocaine users
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 6
- CUD diagnosis
- moderate or severe criteria for substances other than cocaine, cannabis, or nicotine
- unstable psychiatric disorder
- medical conditions contraindicated to TMS (e.g., medical implants, history of seizure or seizure disorder, medications lowering the seizure threshold, neurological conditions, moderate-to-severe heart disease)
- pregnancy
- hairstyles incompatible with the EEG net
- head injury with loss of consciousness
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description iTBS to dmPFC, Then Sham iTBS iTBS to dmPFC - iTBS to dmPFC, Then Sham iTBS Sham iTBS - Sham iTBS, Then iTBS to dmPFC iTBS to dmPFC - Sham iTBS, Then iTBS to dmPFC Sham iTBS -
- Primary Outcome Measures
Name Time Method Amplitude of the Reward Potential (RewP) in Microvolts in Response to Feedback on the Doors Task as Assessed by EEG Immediately after iTBS session The Doors Task will be used to elicit the Reward Potential (RewP) component, representing reward sensitivity. The task is a guessing game, where participants guess which door contains a reward behind it. After selecting a door, the participants are notified if they found the prize by a green arrow pointing up (win) or if they did not find the prize by a red arrow pointing down (loss). The amplitude of the RewP in microvolts in response to feedback is reported.
Amplitude of the Late Positive Potential (LPP) in Microvolts in Response to Visual Stimuli on the Picture Viewing Task as Assessed by EEG Immediately after iTBS session The Picture Viewing Task will be used to elicit the late positive potential (LPP), reflecting the motivational salience of a stimulus. During this task, participants are asked to view a slideshow of images including pleasant, unpleasant, neutral, and cocaine-related images. The amplitude of the LPP in microvolts in response to visual stimuli is reported.
- Secondary Outcome Measures
Name Time Method Craving as Assessed by the Minnesota Cocaine Craving Scale (MCCS) Immediately after iTBS session The first question (intensity of craving) will be used and is measured from 0(none, not at all) to 100(a great deal), higher number indicating more craving.
Cognitive Function as Assessed by the The Montreal Cognitive Assessment (MoCA) Immediately after iTBS session Total score on the Montreal Cognitive Assessment (MoCA) range from 0 to 30, with a higher score indicating a better outcome.
Pain as Assessed by the Visual Analog Scale (VAS) Immediately after iTBS session This is scored from 0(no pain) to 10 (worst pain), higher score indicating greater pain.
Cognitive Function as Assessed by the Montreal Cognitive Assessment (MoCA) Baseline(before iTBS session) Total score on the Montreal Cognitive Assessment (MoCA) range from 0 to 30, with a higher score indicating a better outcome.
Trial Locations
- Locations (1)
The University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States