ICU Echocardiography in Resuscitation of Sepsis and Septic Shock
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Septic Shock
- Sponsor
- Intermountain Health Care, Inc.
- Enrollment
- 700
- Locations
- 1
- Primary Endpoint
- Correlate echo findings and markers of resuscitation
- Last Updated
- 6 years ago
Overview
Brief Summary
BACKGROUND: Echocardiography can provide evaluation of right or left ventricular dysfunction and volume status during resuscitation of patients with sepsis and septic shock and guide intravenous vasopressor and fluid therapy. While there are numerous echocardiographic studies regarding cardiac function and volume status in patients with established shock, there are none that describe these during the early resuscitation of septic shock.
The study objective is to correlate echocardiographic findings with clinical parameters and net fluid balance measured during the early resuscitation of critically ill patients with sepsis and septic shock.
Aim 1) correlate echocardiographic findings of cardiac function with physiologic markers in the early hours of resuscitation
Aim 2) correlate cardiac function and fluid status with clinical outcomes
Aim 3) evaluate the change in cardiac function over time in patients with sepsis and septic shock
Aim 4) evaluate long term clinical outcomes for patients with sepsis and septic shock.
Investigators
Eligibility Criteria
Inclusion Criteria
- •at least 13 years of age
- •SEPSIS PATIENTS:
- •Sepsis patients must have
- •Suspected or confirmed infection
- •Organ dysfunction as defined by a SOFA \>= 2 above baseline (if no baseline data available, SOFA assumed to be 0)
- •SEPTIC SHOCK PATIENTS:
- •AFTER INFUSION OF 20ML/KG CRYSTALLOID OR EQUIVALENT, Septic shock patients must have
- •Suspected or confirmed infection
- •Lactate \> 2 mmol/L
- •Receiving vasopressors
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Correlate echo findings and markers of resuscitation
Time Frame: Within 12 hours of Intensive Care Unit admission
Correlate echocardiographic findings of cardiac function with physiologic markers in the early hours of resuscitation. Specifically, cardiac markers will be analyzed in relation to cardiac function, including ejection fraction, strain, and diastolic function, and correlate these with several clinical parameters, including receipt of fluid, vasopressors, mechanical ventilation, and septic cardiomyopathy