Efficacy of Hyaluronic Acid Gel and Photobiomodulation on Wound Healing After Surgical Gingivectomy

Not Applicable

Completed

• Conditions: Gingival Enlargement
• Interventions: Other: Hyaluronic acid after photobiomodulation; Device: Photobiomodulation

• Registration Number: NCT05787912
• Lead Sponsor: Alexandria University

Brief Summary

The aim of this study was to evaluate the effect of hyaluronic acid gel after photobiomodulation on the healing of surgical gingivectomy sites

Detailed Description

Not available

Study Timeline

• Study Start: 2022-02-01
• Primary Completion: 2023-02-01
• Study Completion: 2023-02-10
• Status Verified: 2023-03
• Study First Submitted: 2023-03-15
• Study First Submitted QC: 2023-03-15
• Last Update Submitted: 2023-03-15
• Study First Posted: 2023-03-28
• Last Update Posted: 2023-03-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Chronic inflammatory gingival enlargement grade 2 and 3 according to the gingival overgrowth index by Miller and Damn.
• Adequate amount of keratinized tissue.
• Attachment loss= 0
• Well educated patients as post-operative instructions need to be followed precisely.

Exclusion Criteria

• Patients with history of smoking
• Pregnant women
• Patients with bad oral hygiene
• Patients who have any known systemic disease that interfere with performance of surgical gingivectomy or periodontal wound healing
• Patients who have any previous adverse reactions to the products (or similar products) used in this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Hyaluronic acid gel after photobiomodulation	Hyaluronic acid after photobiomodulation	-
Photobiomodulation	Photobiomodulation	-

Primary Outcome Measures

Name	Time	Method
Wound healing	up to 21 days	Assessed using Landry's healing index which grades the wound on a scale of 1 (poor) to 5 (excellent); * Very poor (1): ≥50% of gingiva red, bleeding on palpation, Granulation tissue present, Non-epithelialized incision margin with loss of epithelium beyond the margin.; * Poor (2): ≥50% of gingiva red, bleeding on palpation, Granulation tissue present, Non-epithelialized incision margin with exposed connective tissue; * Good (3): ≥25% and\<50% of gingiva red, No bleeding on palpation, no granulation tissue, No exposed connective tissue on the incision margin; * Very good (4): \<25% of gingiva red, No bleeding on palpation, no granulation tissue, No exposed connective tissue on the incision margin; * Excellent (5): All tissues are pink, No bleeding on palpation, no granulation tissue, No exposed connective tissue on the incision margin
Perceived pain	up to 21 days	This was assessed using Visual Analogue Scale (VAS). Patients were instructed to chart their perceptions of pain using VAS ranging from 0-10; where 0 represents no pain/burning sensation and 10 represents severe pain/burning sensation.

Trial Locations

Locations (1)

Faculty of Dentistry, Alexandria University; 🇪🇬 Alexandria, Egypt