Effect of spironolactone on brown fat activity in adult humans

Phase 4

Completed

• Conditions: Obesity; Diet and Nutrition - Obesity

• Registration Number: ACTRN12614001112651
• Lead Sponsor: Professor Ken Ho

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-10-20
• Study Completion: 2016-11-30
• Last Update Posted: 28 March 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

healthy adults aged 18-50 years old, BMI<35

Exclusion Criteria

Pregnancy
eGFR <60

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brown Fat volume changes on 18FDG-PET-CT scan[after two weeks of placebo and after two weeks of spironolactone];Brown fat activity changes on PET-CT[after two weeks of placebo and after two weeks of spironolactone]

Secondary Outcome Measures

Name	Time	Method
Changes in resting energy expenditure using indirect calorimetry<br>[after two weeks of placebo and after two weeks of spironolactone];Changes in diet-induced thermogenesis using indirect calorimetry<br>[after two weeks of placebo and after two weeks of spironolactone]