NL-OMON46185CompletedNot Applicable
The effect of Mirabegron on brown adipose tissue in healthy young white Caucasian and South Asian men - The effect of Mirabegron on brown adipose tissue
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 23
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •* Male volunteers. 10 white Caucasians, born in the Netherlands. 10 South Asians, living in the Netherlands.
- •* Age: 18-30 years
- •* BMI * 25 kg/m2;For the patients the inclusion criteria are:
- •- Male or female
- •- Age: 20-50 years
- •- BMI 18-40 kg/m2
- •- Hetro- of homozygote mutation in LPL or high density lipoprotein-binding protein 1 (HDL-binding protein 1))
Exclusion Criteria
- •* BMI > 25 kg/m2
- •* Recent excessive weight loss or exercise
- •* Alcohol and/ or drugs abuse
- •* Excessive smoking (>10 cigarettes/dag)
- •* Any significant chronic disease, including diabetes, Renal, hepatic or endocrine disease
- •* Heart disease or arrhythmias
- •* Thyroid disease or thyroid medication
- •* Hypertension
- •* Use of medication known to influence glucose and/or lipid metabolism or BAT activity (e.g. beta blockers or calcium channel blockers)
- •* Use of drugs that influence cardiac function or affect QT time
- •* Use of MAO inhibitor
- •* Use of systemic corticosteroids in previous six weeks
- •* Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
- •* Contraindications for undergoing an MRI scan.;For the patients the exclusion criteria are:
- •* Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
- •* Contraindications for undergoing an MRI scan.
Investigators
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