The effect of L-arginine on brown adipose tissue metabolism in South Asian and white Caucasian subjects - L-arginine and brown adipose tissue

Maastricht University0 个研究点开始时间: 2014年10月6日最近更新: 2014年10月27日

适应症

试验速览

暂无简介。

•- Caucasian or South Asian ethnicity
•- Age: 35-50 years
•- Gender: male
•- BMI: 25-30 kg/m2
•- Plasma glucose levels 2 h after OGTT between 7.8 and 11 mM (e.g. impaired glucose tolerance)
•- Plasma L-arginine levels 41 – 114 uM (i.e. within healthy range)
•- Good general health
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 26
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•- Type 2 diabetes (determined on basis of oral glucose tolerance test)
•- BMI > 30 kg/m2
•- Plasma glucose levels 2 h after OGTT < 7.8 mM
•- Plasma L-arginine levels < 41 or > 114 uM
•- Use of beta-blockers < 1 month before start of study or during study
•- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
•- Abuse of drugs and/or alcohol
•- Hyperthyroidism or hypothyroidism
•-Systolic blood pressure < 90 mmHg
•-Haematocrit < 0.41 or > 0.51 l/l
•-Haemoglobin < 8.5 or > 11.0
•-Creatinine (enzymatic method) < 45 or > 100 µmol/L
•-ASAT > 45 U/L
•-ALAT > 50 U/L
•-Alkaline phosphatase > 125 U/L
•-Gamma GT > 45 U/L
•- Participation in earlier research or medical examinations that included PET-CT scanning
•- Psychologically unstable subjects (as judged by the treating medical specialist)
•- Subjects with mental retardation (as judged by the treating medical specialist)
•- Subjects with severe behavior disorders (as judged by the treating medical specialist)

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