NL-OMON44534已完成4 期
The effect of sitagliptin on brown adipose tissue and whole-body metabolism in overweight pre-diabetic men - Sitagliptin and brown adipose tissue
Merck Sharp & Dohme (MSD)0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Male volunteers, 30 Caucasians, born in the Netherlands
- •- Age: 35-55 years
- •- BMI * 25 and * 35 kg/m2
- •- Plasma glucose levels 2 h after OGTT between 7.8 and 11 mM (e.g. impaired glucose tolerance) or fasted plasma glucose >5.6 mM
排除标准
- •- Diabetes mellitus (determined on basis of oral glucose tolerance test (OGTT) defined by ADA criteria
- •- BMI > 35 kg/m2 or < 25 kg/m2
- •- Plasma glucose levels 2 h after OGTT < 7.8 mM or > 11.1 mM
- •- Use of medication known to influence glucose and/or lipid metabolism or BAT activity (e.g. beta blockers)
- •- Any significant chronic disease
- •- Renal, hepatic or endocrine disease
- •- Participation in an intensive weight-loss program or vigorous exercise program during the last year before the start of the study
- •- Difficulties to insert an intravenous catheter
- •- Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
研究者
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