Comparison of the opioid-sparing effect of preemptive and preventive intravenous acetaminophen/ibuprofen fixed-dose combination after hand-assisted laparoscopic nephrectomy: A randomized controlled trial

Ajou University Hospital0 个研究点目标入组 42 人开始时间: 待定最近更新: 2024年4月2日

试验速览

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•A. Patients aged 19 to 80 years undergoing hand-assisted laparoscopic nephrectomy
•B. Patients who can provide written consent to participate in the clinical study, understand the procedures of this clinical study, and appropriately complete the patient-reported questionnaire.
•C. American Society of Anesthesiologists physical status classification (ASA physical status classification) grade 1-2

•A. Patients who did not consent to the study
•B. American Society of Anesthesiologists physical status classification (ASA physical status classification) grade 3-4
•C. Patients who are chronically taking opioids
•D. Patients who have other severe pain at the time of screening, which may cause confusion in pain evaluation
•E. Patients with hypersensitivity to acetaminophen, ibuprofen, fentanyl, or local anesthetics
•F. Patients with a history of gastric ulcer or gastrointestinal bleeding
•G. Patients with liver failure, renal failure, or heart failure
•H. Patients with alcoholism
•I. Patients taking anticoagulant drugs or having blood coagulation abnormalities
•J. Patients with bronchial asthma
•K. Patients with a history of hypersensitivity such as asthma, urticaria, or allergic reaction to aspirin or other non-steroidal anti-inflammatory drugs (including CoX-2 inhibitors)
•L. Patients who find it difficult to complete an abbreviated post-anesthesia recovery questionnaire
•M. Patients taking the following drugs: barbiturates, tricyclic antidepressants
•N. Patients deemed unsuitable for this clinical study according to the opinion of the researcher

发起方

Ajou University Hospital