Effect of General Anesthesia on Enterocyte Damage
- Conditions
- Non-urgent SurgeryGeneral Anesthesia
- Registration Number
- NCT02199275
- Lead Sponsor
- Centre Hospitalier Universitaire de Besancon
- Brief Summary
During non urgent surgery, general anesthesia might induce enterocyte damage. I-FABP is a performant biomarker of enterocyte damage. We aimed to study whether patient ongoing general anesthesia for non-urgent surgery have an elevation of plasma I-FABP concentration.
- Detailed Description
Inclusion criteria
* Indication of non-urgent surgery
* General anesthesia protocol using propofol and remifentanyl
* One half of the patients have a history of ischemic arteriopathy
* One half of the patients have no history of ischemic arteriopathy
Exclusion criteria
* Age \< 18 years old
* Pregnant
Primary objective
Is there a significant elevation of I-FABP between the pre-anesthesic period and 11 minutes after induction of general anesthesia ?
Secondary objectives
1. Is I-FABP elevation higher among patients with history of patent arteriopathy ?
2. Is I-FABP elevation higher among patients presenting with hypotension during anesthesia ?
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method I-FABP elevation after induction of general anesthesia 11 minutes Primary measure of plasma I-FABP before induction of general anesthesia. Second measure of plasma I-FABP concentration 11 minutes after induction of general anesthesia using a protocol of propofol and remifentanyl with monitoring of bispectral index.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHRU de Besançon
🇫🇷Besançon, France