Immature Myeloid Cells in Respiratory Syncytial Virus Bronchioliltis
- Conditions
- Bronchiolitis
- Interventions
- Other: Respiratory secretions obtained
- Registration Number
- NCT01684527
- Lead Sponsor
- Hillel Yaffe Medical Center
- Brief Summary
The investigators hypothesize that Respiratory Syncytial Virus (RSV) infection may influence the population of lung immature myeloid cells and dendritic cells in a way that will impair their ability to invoke an effective immune response and lead to prolonged inflammation, angiogenesis and scarring. This may lead in turn to disturbed lung function.
Our aim is to determine the presence and phenotype of immature myeloid cells present in respiratory secretions of children with RSV bronchiolitis as compared to non-RSV bronchiolitis and healthy controls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 55
Inclusion Criteria
- Bronchiolitis
Exclusion Criteria
- Chronic disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Children Suffering From Bronchiolitis Respiratory secretions obtained Respiratory secretions obtained from children suffering from Bronchiolitis Healthy Children Respiratory secretions obtained Respiratory secretions obtained from children with no respiratory infection
- Primary Outcome Measures
Name Time Method Number of Immature Myeloid Cells in Respiratory Secretions Participants will be followed for the duration of hospital stay, an expected average of one week Respiratory secretions obtained from child presenting with bronchiolitis will be examined for the presence of immature myeloid cells
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hillel Yaffe Medical Center
🇮🇱Hadera, Israel