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Clinical Trials/NCT01478165
NCT01478165
Completed
Not Applicable

Comparative Study of TIVA(Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing PONV(Postoperative Nausea and Vomiting)

Incheon St.Mary's Hospital1 site in 1 country100 target enrollmentSeptember 2011
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ConditionsPostoperative Nausea and Vomiting
InterventionsTotal intravenous anesthesiaTotal intravenous anesthesia plus palonosetron
DrugsTotal intravenous anesthesiaTotal intravenous anesthesia plus palonosetron

Overview

Phase
Not Applicable
Intervention
Total intravenous anesthesia
Conditions
Postoperative Nausea and Vomiting
Sponsor
Incheon St.Mary's Hospital
Enrollment
100
Locations
1
Primary Endpoint
Incidence of postoperative nausea and vomiting
Status
Completed
Last Updated
14 years ago
OverviewInvestigatorsEligibility CriteriaArms & InterventionsOutcomesSitesSimilar Trials

Overview

Brief Summary

A total intravenous anesthesia (TIVA) is a useful anesthetic technique that reduces the incidence of postoperative nausea and vomiting (PONV).

Investigator hypothesized the incidence of PONV can be further reduced when palonosetron is added to TIVA.

Registry
clinicaltrials.gov
Start Date
September 2011
End Date
November 2011
Last Updated
14 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Sponsor
Incheon St.Mary's Hospital
Responsible Party
Principal Investigator
Principal Investigator

Soo Kyoung Park

Clnical professor

Incheon St.Mary's Hospital

Eligibility Criteria

Inclusion Criteria

  • •ASA Physical Status 1 or 2
  • •Elective gynaecological laparoscopic surgery of ≥ 1h duration

Exclusion Criteria

  • •Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation
  • •Vomiting or retching in the 24 h preceding surgery
  • •Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry
  • •Ongoing vomiting from gastrointestinal disease

Arms & Interventions

Tiva group (Group T)

Intervention: Total intravenous anesthesia

TIVA plus palonosetron group (Group T+P)

Intervention: Total intravenous anesthesia plus palonosetron

Outcomes

Primary Outcomes

Incidence of postoperative nausea and vomiting

Time Frame: For 24 hours after surgery

Secondary Outcomes

  • Severity of nausea(For 24 hours after surgery)

Study Sites (1)

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