Study on the effect of prednisolone on muscle strength and mobility
- Conditions
- ANCA associated vasculitis, Steroid myopathy, Glucocorticoid toxicity
- Registration Number
- NL-OMON24482
- Lead Sponsor
- niversity Medical Center Groningen (UMCG)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Patients with new onset or relapse of Granulomatosis with Polyangiitis or Microscopic Polyangiitis, who have an indication of induction treatment with cyclophosphamide (or other immunosuppressive) and prednisolone (1mg/kg/day, dosage according to treatment protocol)
Exclusion Criteria
Patients <18 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -Strength of knee extension and hip flexion (N), measured by handheld dynamometer<br /><br>-Mobility (average kcounts/day), measured by accelerometer<br /><br>-Physical summary score of RAND-36
- Secondary Outcome Measures
Name Time Method These include anthropometric measures, strenght of elbow flexors, bioelectric impedance analysis, five-times sit-to-stand transfer and mobility questionnaires