Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery

HealthPartners Institute1 site in 1 country47 target enrollmentJanuary 6, 2020

ConditionsPost Operative Cognitive Dysfunction

Overview

Phase: N/A
Intervention: Not specified
Conditions: Post Operative Cognitive Dysfunction
Sponsor: HealthPartners Institute
Enrollment: 47
Locations: 1
Primary Endpoint: Presence of Post Operative Cognitive Dysfunction (POCD)
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Post-operative cognitive dysfunction (POCD) is a common concern for aging patients undergoing elective orthopedic surgery and significantly effects health outcomes. This study aims to evaluate the incidence of and risk factors associated with post-operative cognitive dysfunction in aging patients without prior history for mild cognitive impairment or dementia.

Registry

clinicaltrials.gov

Start Date

January 6, 2020

End Date

June 14, 2023

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

HealthPartners Institute

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age ≥50 and ≤90
•Any patient undergoing elective orthopedic surgery for hip, knee, or shoulder replacement (as defined by diagnostic codes: M16.0, M16.12, M16.11, M17.0, M17.12, M17.11, M19.011, M19.012)

Exclusion Criteria

•History of cognitive impairment of dementia
•Montreal cognitive assessment (MoCA) \<26
•History of Parkinson's disease, progressive supranuclear palsy, corticobasal degeneration, normal pressure hydrocephalus, Huntington's disease, stroke, seizure disorder, brain tumor, or brain surgery
•History of surgery requiring anesthesia within the past 3 months

Outcomes

Primary Outcomes

Presence of Post Operative Cognitive Dysfunction (POCD)

Time Frame: 3 months

Defined as a decline of 1.5 or greater standard deviation on any one of the cognitive test performed from baseline to three-months post surgery. Score range: 0-100. A higher score indicates more cases of incident of POCD.