Postoperative Cognitive Dysfunction After Intravenous Anesthesia or Closed-loop Coadministration of Propofol and Remifentanil Guided by Bispectral Index for Noncardiac Surgery : a Randomized Monocenter Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Patients ASA I, II, III
- Sponsor
- Centre Hospitalier Universitaire de Besancon
- Enrollment
- 204
- Locations
- 1
- Primary Endpoint
- the incidence of early POCD in elderly patients (aged 55 yrs or older)
- Last Updated
- 9 years ago
Overview
Brief Summary
Background: Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem.
Therefore,this study was designed to assess POCD after closed-loop coadministration of propofol and remifentanil guided by bispectral index in comparison to intravenous anesthesia in elderly patients undergoing major noncardiac surgery. Methods: After approval of the local ethical committee was obtained, 204 patients (American Society of Anesthesiologists physical status I-III; age, > 55 yr) undergoing surgery (duration, > 1 h) were enrolled into this pospective randomized monocenter study. Patients received anesthesia 3 days after using a neuropsychological test battery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists physical status I-III;
- •undergoing surgery (duration, \> 1 h)
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
the incidence of early POCD in elderly patients (aged 55 yrs or older)
Time Frame: 3 DAYS