Postoperative Cognitive Dysfunction After Intravenous Anesthesia or Closed-loop Coadministration of Propofol and Remifentanil Guided by Bispectral Index for Noncardiac Surgery : a Randomized Monocenter Study
试验速览
- 阶段
- 不适用
- 入组人数
- 204
- 试验地点
- 2
- 主要终点
- the incidence of early POCD in elderly patients (aged 55 yrs or older)
研究概览
简要总结
Background: Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem.
Therefore,this study was designed to assess POCD after closed-loop coadministration of propofol and remifentanil guided by bispectral index in comparison to intravenous anesthesia in elderly patients undergoing major noncardiac surgery. Methods: After approval of the local ethical committee was obtained, 204 patients (American Society of Anesthesiologists physical status I-III; age, > 55 yr) undergoing surgery (duration, > 1 h) were enrolled into this pospective randomized monocenter study. Patients received anesthesia 3 days after using a neuropsychological test battery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists physical status I-III;
- •undergoing surgery (duration, > 1 h)
排除标准
- 未提供
研究组 & 干预措施
CLOSED LOOP ANESTHESIA
neuropsychological test battery
干预措施: neuropsychological test battery (Procedure)
INTRAVENOUS ANESTHESIA
neuropsychological test battery
干预措施: neuropsychological test battery (Procedure)
结局指标
主要结局
the incidence of early POCD in elderly patients (aged 55 yrs or older)
时间窗: 3 DAYS
次要结局
未报告次要终点