Postoperative Cognitive Dysfunction After Propofol Anesthesia for Noncardiac Surgery
Not Applicable
- Conditions
- Patients ASA I, II, III
- Interventions
- Procedure: neuropsychological test battery
- Registration Number
- NCT02841423
- Lead Sponsor
- Centre Hospitalier Universitaire de Besancon
- Brief Summary
Background: Postoperative cognitive dysfunction (POCD) in elderly patients after noncardiac surgery is a common problem.
Therefore,this study was designed to assess POCD after closed-loop coadministration of propofol and remifentanil guided by bispectral index in comparison to intravenous anesthesia in elderly patients undergoing major noncardiac surgery. Methods: After approval of the local ethical committee was obtained, 204 patients (American Society of Anesthesiologists physical status I-III; age, \> 55 yr) undergoing surgery (duration, \> 1 h) were enrolled into this pospective randomized monocenter study. Patients received anesthesia 3 days after using a neuropsychological test battery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 204
Inclusion Criteria
- American Society of Anesthesiologists physical status I-III;
- undergoing surgery (duration, > 1 h)
Exclusion Criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description CLOSED LOOP ANESTHESIA neuropsychological test battery neuropsychological test battery INTRAVENOUS ANESTHESIA neuropsychological test battery neuropsychological test battery
- Primary Outcome Measures
Name Time Method the incidence of early POCD in elderly patients (aged 55 yrs or older) 3 DAYS
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chu Besancon
🇫🇷Besancon, France