Metabolite Identification after Polyphenol Ingestion in Adults

Not Applicable

Completed

• Conditions: rine and blood biomarkers after consumption of dietary polyphenols; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN15516017
• Lead Sponsor: Kao Corporation (Japan)

Brief Summary

1. 2016 results in: DOI: 10.1016/j.foodres.2016.03.038 2. 2018 results in: DOI: 10.1021/acs.jafc.8b04198

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2014-07-10
• Study Start: 2014-12-10
• Last Update Posted: 18 March 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

1. Healthy volunteers aged 20 to 59 years
2. Male
3. Normal weight or overweight (body mass index 18.5-29.9 kg/m2)

Exclusion Criteria

1. Caffeine intoxication
2. Food allergy
3. Intake of catechins or chlorogenic acid supplements
4. Serious illness (such as heart disease, kidney disease, diabetes and so on)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Metabolomic profiles of urine and blood which associate with indirect calorimetry; Timepoints: baseline (before intervention period), after 4-week intervention period, fasting and postprandial states

Secondary Outcome Measures

Name	Time	Method
Metabolomic profiles of urine and blood which associate with the polyphenol intake; Timepoints: baseline (before intervention period), after 4-week intervention period, fasting and postprandial states