DOSE-dependent response of polyphenols from GRAPE extract on polyphenols bioavailability
Not Applicable
Completed
- Conditions
- Concentration of polyphenols in urine and their kinetics in plasmaNot Applicable
- Registration Number
- ISRCTN06777936
- Lead Sponsor
- Ministry of Economy and Competitiveness ? INNPRONTA (Miguel Torres S.A) (Spain)
- Brief Summary
1. 2017 results in https://www.ncbi.nlm.nih.gov/pubmed/28964366 (added 22/01/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Healthy adults (females and males), aged 20-40 years
Exclusion Criteria
1. Previous history of cardiovascular disease (ischemic heart disease - angina or recent or old myocardial infarction, cerebral vascular accident, or peripheral vascular disease)
2. Homeostatic disorders
3. Any several chronic diseases
4. Hypertension or dyslipidemia
5. Grape intolerance or allergic
6. Smoking subjects
7. Alcoholism
8. Other toxic abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Polyphenols will be identified through liquid chromatography coupled to Orbitrap mass spectrometry. Concentrations of polyphenols will be quantified by liquid chromatography coupled to tandem mass spectrometry (LC?MS/MS). Polyphenols will be quantified at 0 to 24 hours of each intervention.
- Secondary Outcome Measures
Name Time Method <br> Before (0 hours) and after each intervention (6 hours) the following measures were taken:<br> 1. Blood pressure<br> 2. Body weight<br> 3. Waist perimeter<br> 4. Glucose<br> 5. Lipid profile<br> 6. Biomarkers of oxidative stress and systematic inflammation<br> 7. Coagulation factor and vitamin levels<br>