Bioavailability of beetroot compounds in older adults

Not Applicable

Completed

• Conditions: Age-related degenerative diseases; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN86706442
• Lead Sponsor: ewcastle upon Tyne Hospitals NHS Foundation Trust

Brief Summary

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/34718635/ (added 08/11/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-24
• Study Completion: 2017-12-22
• Last Update Posted: 20 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

1. Non-obese
2. Non-smoker
3. Males aged between 18 and 35 or 60 and 75 years
4. Free of chronic illness

Exclusion Criteria

1. Vegetarianism
2. High blood pressure
3. Active cancer and any diagnosis of malignant cancer in the last 5 years
4. Diagnosis of chronic and acute metabolic and inflammatory conditions interfering with the study outcome
5. Medications that may have an effect on NO production
6. Hormonal therapies, statins and psychiatric drugs if dose started/changed in previous 3 months
7. Haematological disorders
8. History of repetitive gastric reflux
9. Excessive alcohol intake
10. Allergy or intolerance to the intervention food
11. Under the age of 18
12. Smoker

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in bioavailability of nitrate between incremental doses of beetroot and compared to a standard dose of potassium nitrate at 5 hours

Secondary Outcome Measures

Name	Time	Method
<br> 1. Differences in changes in blood pressure following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours<br> 2. Differences in changes in endothelial function following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours<br> 3. Differences in changes in exhaled nitric oxide following each dose of nitrate supplementation and compared to a standard dose of potassium nitrate at 5 hours<br> 4. Differences in bioavailability of betalains and phenolic compounds between incremental doses of beetroot and compared to a standard dose of potassium nitrate at 5 hours<br>