Role of Intra-articular and Intra-osseous injections of Platelet Rich Plasma in OA Knee - IA and IO injections of PRP in OA Knee

All India Institute of Medical Sciences Bhubaneswar0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1.Patients aged 40-65 years, who are able to walk with a painful knee and fulfilled the criteria for knee OA of the medial femorotibial joint, as defined by the American College of Rheumatology (ACR).
•2.Persisting Knee Pain due to OA Knee (Grade II/III, according to the radiological classification of knee OA defined by Kellgren and Lawrence)
•3.Pain of at least 20 mm on a 0-100mm VAS when asked: â??how painful is your knee during level walking?â??
•4.If both knees involved, participants choose one or both knees to be treated.
•5.Willing to participate in all assessment

•1)Severe OA Knee (Grade IV, according to Kellgren and Lawrence classification)
•2)Haemoglobin level < 10gm%
•3)Inflammatory or post-infectious knee arthritis
•4)History of prior knee replacement repair
•5)Prior fracture of the knee joint
•6)Any Knee injection within 3 months
•7)Daily use of opioid medication
•8)Coexisting Backache, other chronic pain disorder
•9)Body mass index (BMI) greater than 40 kg/m2
•10)Blood disorders, hematological, cardiac, hepatic or renal disorders.
•11)Patients who had received either an oral, topical or intra-articular steroid during the four weeks before the study pregnancy
•12)Co-morbidity severe enough to prevent participation in the study protocol including at-home exercise or attendance at scheduled injection appointments.

发起方

All India Institute of Medical Sciences Bhubaneswar