Own blood product injection into joint and in bone in Osteoarthritis Knee

Not Applicable

• Conditions: Health Condition 1: M170- Bilateral primary osteoarthritis of knee

• Registration Number: CTRI/2019/04/018613
• Lead Sponsor: All India Institute of Medical Sciences Bhubaneswar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Patients aged 40-65 years, who are able to walk with a painful knee and fulfilled the criteria for knee OA of the medial femorotibial joint, as defined by the American College of Rheumatology (ACR).

2.Persisting Knee Pain due to OA Knee (Grade II/III, according to the radiological classification of knee OA defined by Kellgren and Lawrence)

3.Pain of at least 20 mm on a 0-100mm VAS when asked: â??how painful is your knee during level walking?â??

4.If both knees involved, participants choose one or both knees to be treated.

5.Willing to participate in all assessment

Exclusion Criteria

1)Severe OA Knee (Grade IV, according to Kellgren and Lawrence classification)

2)Haemoglobin level < 10gm%

3)Inflammatory or post-infectious knee arthritis

4)History of prior knee replacement repair

5)Prior fracture of the knee joint

6)Any Knee injection within 3 months

7)Daily use of opioid medication

8)Coexisting Backache, other chronic pain disorder

9)Body mass index (BMI) greater than 40 kg/m2

10)Blood disorders, hematological, cardiac, hepatic or renal disorders.

11)Patients who had received either an oral, topical or intra-articular steroid during the four weeks before the study pregnancy

12)Co-morbidity severe enough to prevent participation in the study protocol including at-home exercise or attendance at scheduled injection appointments.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual analogue pain Score (0-10cm) <br/ ><br>Timepoint: 0 month (V1), 1.5 months (V2), 3 months (V3)

Secondary Outcome Measures

Name	Time	Method
KOOS questionnaire (0-100) <br/ ><br> <br/ ><br>Range of motion of affected knee jointTimepoint: 0 month, 1.5 months, 3 months