Safety and efficacy of intra-articular injections of platelet-rich plasma for the treatment of osteoarthritis of the knee in the Japanese populatio
- Conditions
- Osteoarthritis of the knee
- Registration Number
- JPRN-UMIN000011829
- Lead Sponsor
- niversity of Tsukuba Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 10
Not provided
1. Requiring infiltration in both knees 2. BMI more than 33 3. Suffering from polyarticular disease 4. Previous knee arthroscopy within last year 5. HA or steroid intra-articular infiltration within last 3 months 6. Past history of infectious disease 7. Compromised host 8. Systemic autoimmune disease 9. Anemia with hemoglobin under 10g/dl 10. Blood disorders 11. Treatment with anticoagulant drugs (Aspirin, Warfarin) 12. Having undergone treatment with steroids during 3 months before inclusion in this study 13. Treatment with NSAIDs during 2 weeks before its inclusion in this study 14. Patients who had malignancy during 5 years before inclusion in this study 15. Patients who do not have a voluntary consent capacity 16. Patients who cannot have a consent with document 17. Patients whom the doctor has determined that it is not suitable for this clinical study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Adverse events during the treatment and follow-up period. 1. Shock 2. Pain and stiffness 3. Swelling 4. Local heat
- Secondary Outcome Measures
Name Time Method 1. The percentage of patients having a 50% decrease in the summed score for the Visual Analogue Scale from baseline to week 24. 2. Serum hyaluronic acid concentration rate before and after treatment 3. Improvement of felction and extension angle of the knee 4. Improvement rate of Japanese Knee Osteoarthritis Measure 5. Improvement of Japanese Orthopaedics Association score