To compare the efficacy of intraarticular injection of platelet rich plasma with bupivacaine and steroid combination in osteoarthritis knee and to assess improvement in pain score and patient satisfaction.

Not Applicable

Completed

• Conditions: Health Condition 1: M179- Osteoarthritis of knee, unspecified

• Registration Number: CTRI/2021/05/033331
• Lead Sponsor: Pt BD Sharma PGIMS Rohtak

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2022-01-10
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Fifty patients of either sex, age more than 50 years, attending Pain Clinic and fulfilling following three criteria will be included in the study:

History, physical examination and pain pattern consistent with osteoarthritis of knee

X-ray knee joint findings corresponding with the patient’s clinical symptoms

Failure to respond to six weeks of conservative treatment.

Exclusion Criteria

Patients with

History of uncontrolled diabetes mellitus

History of immunodeficiency, collagen vascular disorders or autoimmune disorders

Infection or active wound in the knee area

Recent history of severe trauma to the knee or knee surgery

History of treatment with anticoagulants and antiplatelet drugs 10 days before injection

History of NSAID use two days before injection

History of intra-articular steroid injection in the past three months

History of systemic use of steroid two weeks before the injection

Hb values <10g/dl or platelet values <1,50,000 per cmm-1

History of adverse drug reaction to local anesthetics or steroids

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of pain using pain scoreTimepoint: Half hour before procedure <br/ ><br>Half hour after procedure <br/ ><br>2 weeks after procedure <br/ ><br>1 month after procedure <br/ ><br>2 months after procedure <br/ ><br>3 months after procedure

Secondary Outcome Measures

Name	Time	Method
The Western Ontario and McMaster Universities (WOMAC) Index of OsteoarthritisTimepoint: The WOMAC Index will be calculated half hour before the procedure; two weeks, one month, two months and three months after the procedure.;Patient satisfaction <br/ ><br>Timepoint: Patient satisfaction will be assessed two weeks, one month, two months and three months after the procedure.