influence of preload on repolarization (iPORT)

Completed

• Conditions: heart rhythmdisorders; repolarization dependent ventricular arrhythmias; 10007521

• Registration Number: NL-OMON43942
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 35

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:
* *18 years of age
* Structural normal heart based on present clinical information (echocardiography, electrocardiogram)
* Indication for an electrophysiological procedure based on a narrow complex tachycardia (presumed);
o Concealed bypass
o Atrioventricular node re-entry tachycardia (AVNRT)
o Ectopic atrial tachycardia

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study:;* Use of anti-arrhythmic medication
* Atrial fibrillation at time of the stimulation protocol.
* Any possibility of electrical remodelling of the ventricle;
o The presence of an antidrome circle tachycardia; Wolf Parkinsson White syndrome (as due to the pre-excitation of the ventricles over the bypass some ventricular electrical remodelling can be expected).
o History of persistent atrial fibrillation (AF); due to persistent AF the ventricles are stimulated irregularly and aberrant conduction could induce electrical remodelling of the ventricle.
o History of frequent ventricular extrasystoli.;Exclusion criteria after informed consent is signed;
o At time of the electrophysiological procedure an on-going narrow complex tachycardia (as this will intervene with the stimulation protocol and will make the ecg*s unsuitable for STV QT analysis).
o During the stimulation protocol a large number of ventricular extra systoles (*5) or any other reason making the ecg*s unsuitable for STV QT analysis (e.g. movement artefacts)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is beat to beat variability of repolarization (BVR)<br /><br>measured as short term variability of the QT interval (STV QT) of 31<br /><br>consecutive beats on a 12-leads surface ecg. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable.</p><br>