Effects of sprint training in type 1 diabetes

Completed

• Conditions: Type 1 diabetes mellitus; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12606000368538
• Lead Sponsor: Dr Alison Harmer

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-08-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Group with type 1 diabetes, inclusion: diabetes for at least 1.5 yrs; taking no medications other than insulin; no evidence of diabetic complications such as proliferative retinopathy (>10 microaneurysms in previous year) or autonomic or peripheral neuropathies; HbA1c < 10%.
Non-diabetic control group, inclusion: no history or family history of any metabolic disorder.
Both groups, inclusion: not currently undertaking high-intensity exercise training; non-smokers; no medications.

Exclusion Criteria

Group with type 1 diabetes, exclusions: taking mediaction other than insulin; HbA1c >10%; presence of diabetic complications; diabetes for < 1.5 years.
Non-diabetic control group, exclusions: taking medication; family or personal history of metabolic disorders.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle (vastus lateralis) sodium potassium adenosine triphosphatase (Na+K+ATPase) content[Measured at rest at 0 and 8 weeks of training];Muscle [lactate][Measured before and immediately after a high intensity exercise at 0 and 8 weeks of training only]

Secondary Outcome Measures

Name	Time	Method
Glycosylated haemoglobin (HbA1c)[Measured at rest at 0 and 8 weeks];Plasma glucose[Measured at 0 and 8 weeks during a high-intensity exercise test at rest, immediately after exercise, and at 1, 2, 5, 10, 20, 30, 45, and 60 min of recovery.];Plasma potassium (K+) - measured as per glucose[];Plasma hydrogen ion (H+) - measured as per glucose[];Plasma lactate concentration - measured as per glucose[];Muscle pyruvate concentration- measured as per primary outcome of muscle lactate[];Catecholamines[Measured during a high intensity exercise test at 0 and 8 weeks at rest, immediately after exercise, and at 1, 2, 5, 10, 20 and 60 min recovery.];Plasma glucose, plasma potassium and plasma hydrogen ion concentration[Measured before and after 4 x 30 s cycle sprints and at 4, 5, 12, and 20 min recovery, both at 0 weeks and in the final training session of week 7.]