Can More Sleep Improve Pain Responses, Symptomatology, and Regulation in College Students?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Change in thermal pain tolerance from before to after sleep extension
研究概览
简要总结
This study is being done to find out whether extending sleep for at least an hour per night, seven days a week, predicts a higher tolerance and a higher threshold for pain. This is a 21-day study. Participants will be asked to wear sleep- and heart- monitoring watches. Pressure pain and cold pain will be measured at study visits.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 24 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 24 (inclusive) years of age at enrollment
- •Fluent English speaker and reader
- •Willing to refrain from initiating new therapeutic interventions (e.g., medication; behavioral) designed to target sleep or pain for the duration of study participation
排除标准
- •Diagnosed with a sleep disorder
- •Diagnosed with a pain disorder
- •Has experienced a cold-related injury frostbite or has any other nerve damage to the feet
- •Has a history of injury to any of the muscular measurement sites for pain (I.e. shoulder, jaw, forearm)
- •Diagnosed with hypertension or cardiovascular disease
- •Evidence of hypertension
- •Diagnosed serious mental health disorder or substance use disorder
- •Taking any physician-directed pharmacologic intervention for sleep
- •Taking any physician-directed pharmacologic intervention for pain
- •Personal health history of traumatic brain injury
- •Current smoker
研究组 & 干预措施
Sleep Extension
1 week of >1 hour increased time in bed
干预措施: Sleep extension (Behavioral)
Control
Sustained sleep behavior
结局指标
主要结局
Change in thermal pain tolerance from before to after sleep extension
时间窗: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
Latency to respond to a bilateral cold pressor test (feet). A longer latency to tolerance indicates better pain response.
Change in pressure pain threshold from before to after sleep extension
时间窗: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
Bilateral response to a clinically standard algometer at 3 different physical palpation sites. A higher pressure reading indicates a better pain response.
Change in pain inhibition from before to after sleep extension
时间窗: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
Pain inhibition is measured as the difference in pressure pain threshold from before to after cold pressor procedure. A reduction in pressure pain threshold is typical after cold pressor procedure. A greater reduction in pain threshold indicates a better response of the pain inhibitory system.
Change in pressure pain tolerance from before to after sleep extension
时间窗: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
Bilateral response to a clinically standard algometer at 3 different physical palpation sites. A higher pressure reading indicates a better pain response.
Change in weekly average of momentary pain self-reports from before to after sleep extension
时间窗: (averaged) Daily surveys during study week 1 (pre-intervention) and study week 2 (intervention)
Intermittent pain intensity using a Visual Analog Scale (0-100, where 0 = "no pain", 100 = "worst pain imaginable in current circumstances"). Higher values indicated more pain, and a negative change indicates a decrease in pain.
Change in thermal pain threshold from before to after sleep extension
时间窗: Momentary at study visit 2 (at the end of week1) and a week later at study visit 3 (at the end of week2).
Latency to respond to a bilateral cold pressor test (feet). A longer latency to threshold indicates better pain response.
次要结局
未报告次要终点
研究者
Anne-Marie Chang
Associate Professor
Penn State University