Exploratory Study of Ultrasound Signs of Native Septic Arthritis of the Knee

Recruiting

• Conditions: Ultrasound Therapy; Complications; Septic Arthritis; Knee Arthritis
• Interventions: Device: ultrasound

• Registration Number: NCT04952220
• Lead Sponsor: Poitiers University Hospital

Brief Summary

Primary objective: Description of ultrasound abnormalities seen in native septic arthritis of the knee during each visit.

Primary endpoint: Describe the ultrasound abnormalities observed on Day 0, Day 10, 6 weeks, 3 months, 6 months, during native septic arthritis of the knee.

Detailed Description

Secondary Objectives:

1. Search for poor prognostic factors in native septic arthritis of the knee.

2. To look for an association between initial sonographic factors and the use of joint lavage.

3. Look for associations between sonographic signs and clinico-radio-biologic factors at each visit (D10, 6 weeks, 3 months and 6 months)

Study Timeline

• Study First Submitted: 2021-06-16
• Study First Submitted QC: 2021-07-04
• Study First Posted: 2021-07-07
• Study Start: 2021-10-27
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-18
• Last Update Posted: 2024-01-19
• Primary Completion: 2025-04
• Study Completion: 2025-10

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Male or female of legal age
• Bacteriologically proven native septic arthritis
• Meets the definition of septic arthritis: Bacteriological documentation of joint puncture fluid-Native articulation
• Free subject, without guardianship or trusteeship, or subordination
• Non-opposition of the patient after clear and fair information about the study

Exclusion Criteria

• Presence of material in the affected joint
• Arthritis with Mycobacterium Tuberculosis.
• Patients benefiting from a reinforced protection, namely: minors, pregnant and/or breast-feeding women, persons deprived of liberty by a judicial or administrative decision, adults under legal protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
native septic arthritis of the knee	ultrasound	Describe the ultrasound abnormalities observed at D0, D10 or before surgery, 6 weeks, 3 months, 6 months, during native septic arthritis of the knee: thickness and vascularity of the synovial membrane, existence and measurement of joint effusion existence of articular partitioning, erosions and adjacent soft tissue involvement (muscle abscess, cellulitis)

Primary Outcome Measures

Name	Time	Method
description of the ultrasound abnormalities seen in native septic arthritis of the knee	Day0, Day 10 or before surgery, 6week, 3months, 6months	Describe the ultrasonographic abnormalities seen in native septic arthritis of the knee

Trial Locations

Locations (7)

CH D'Angouleme; 🇫🇷 Angoulême, France

CHU de Nantes; 🇫🇷 Nantes, Pays De La Loire, France

CH de Niort; 🇫🇷 Niort, France

CH de La roche-sur-yon; 🇫🇷 La Roche-sur-Yon, France

CH De La Rochelle; 🇫🇷 La Rochelle, France

CHU de Poitiers; 🇫🇷 Poitiers, France

CHU de Rennes; 🇫🇷 Rennes, France