Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study
Recruiting
- Conditions
- Hypophosphatasia
- Interventions
- Diagnostic Test: Second alkaline phosphatase measurement
- Registration Number
- NCT06574282
- Lead Sponsor
- University of Bonn
- Brief Summary
Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis
- Detailed Description
Acronym: Expansion:
HPP =Hypophosphatasia COHIR ="Characteristics of Hypophosphatasia in Adult Patients in Rheumatology" ALPL =Alkaline Phosphatase
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 720
Inclusion Criteria
- Written informed consent
- Age > 18 years
- Clinical suspicion of hypophosphatasia
- Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening
Exclusion Criteria
- Failure to meet the inclusion criteria listed above
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Persistant hypophosphatasemia Second alkaline phosphatase measurement - Transient hypophosphatasemia (Control group without hypophosphatasia) Second alkaline phosphatase measurement -
- Primary Outcome Measures
Name Time Method Prevalence of hypophosphatasia in adult patients in rheumatology 36 months The primary aim of this prospective observational study is to determine the prevalence of hypophosphatasia in adult patients presenting with musculoskeletal symptoms in rheumatology.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn
🇩🇪Bonn, North Rhine-Westphali, Germany