The effect of Clonidine and Dextromethorphan on cold pain threshold
Phase 3
- Conditions
- The pain induced by cold.Superficial frostbite of wrist and hand
- Registration Number
- IRCT2016020826447N1
- Lead Sponsor
- Student's Scientific Research Center of Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
Inclusion Criteria: Complete physical and mental health; Informed consent to participate in the study; 18-45 years of age; No cigarette smoking and coffee use; No history of taking anti depressant and analgesic medications.
Exclusion Criteria
Acute or chronic pain; Pregnancy; Gastrointestinal bleeding; Renal or liver disease; Asthma; Diabetes; Hyper tension; Mental and, or neurological disease; Hyper sensitivity to Clonidine and Dextromethorphan.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cold pain threshold. Timepoint: Before interventions, First day(After taking pills available in packet No.1), 11th day(after taking pills available in packet No.2), 21th day(After taking pills available in packet No.3), 31th day(After taking pills available in packet No.4), 41th day(After taking pills available in packet No.5). Method of measurement: The maximum storage time (in minutes) in a mixture of water and ice.
- Secondary Outcome Measures
Name Time Method